What is prostaglandins?
Prostaglandins (Pg) are a group of lipid physiologically active substances formed in the body by enzymatic means from certain essential fatty acids and containing a 20-membered carbon chain. Prostaglandins are found in virtually all tissues and organs.
Interesting facts about prostaglandins
Interestingly, aspirin, indomethacin and ibuprofen are inhibitors (substances slowing or preventing the course of any chemical reaction) of prostaglandin synthesis, blocking the synthesis of prostaglandins, they slow down hair growth.
Any woman during sex is given a huge amount of prostaglandin, which guarantees a good contraction of the uterus during childbirth and is contained in large quantities in the sperm of a man. Counting the isolation of the cervix uteri prostaglandin is considered that having sex also stimulates the onset of labor.
Prostaglandin F2α (PGF2α / Prostaglandin F2alpha) is a precursor of prostaglandins for eyelashes.
Prostaglandin F2α (PGF2α / Prostaglandin F2alpha) is widely used in medicine in obstetrical practice.
Means with synthetic analogues of prostaglandin F2α (PGF2α) were created artificially and were originally used in ophthalmology to reduce intraocular pressure (IOP) and for the treatment of glaucoma.
The amazing side effect of prostaglandins is the growth of long eyelashes
However, it has been observed that patients using drugs with prostaglandin analogues F2α (PGF2α / Prostaglandin F2alpha) such as travoprost, latanoprost and prostaglandins such as bimatoprost have a very interesting side effect. This effect consisted of picturesquely long, dark, fluffy eyelashes, so far-off and dramatic that they could easily be confused with overhead or narrown.
Prostaglandins in cosmetology and hypotrichosis
Latisse (Latisse) - a gift from the company Allergan (Allergan), has already given the world Botox (Botox).
Naturally, pharmaceutical companies were quick to benefit from this, and on December 5, 2008, after clinical studies of eye drops of Lumigan as a cosmetic drug, Allergan ensured that the FDA (Food and Drug Administration), or rather its The Dermatologic and Ophthalmic Drugs Advisory Committee voted in favor of the recognition of bimatoprost, the main ingredient of drops, suitable for use in cosmetology as a means of A lengthening of the eyelashes and utemneniya.
Thus, the first patented lash extension, authorized by the FDA for use in the US as a means to increase eyelash growth, was Latisse, owned by the Allergan brand, the main active ingredient of which was bimatoprost.
What is the FDA, there is a reliable organization?
The FDA (Food and Drug Administration) is a very serious organization and it allows only those drugs that are safe to be safe to use or the risk of complications is not significant compared to the expected benefits. FDA allowed the use of the drug exclusively for cosmetic purposes in patients with hypotrichosis / hypotrichosis (eyelid hypotrichosis).
The advantages of using prostaglandins for the growth of eyelashes
What benefit do we get from using bimatoprost and other prostaglandins to increase eyelash growth? It is noted that bimatoprost and other prostaglandins cause lengthening of the eyelashes, thickening of the hair - the eyelashes look stronger and thicker, as well as an increase in the pigmentation of the eyelashes - that is, they become darker.
How does the eyelashes with prostaglandins work? What is the mechanism of action of prostaglandins?
Despite the existence of a mechanism for the metabolism of prostaglandins and receptors to prostaglandins in the hair follicles, the mechanism by which prostaglandins and prostamins trigger the growth of the eyelashes is not entirely clear.
There is a version that hair growth is caused by prostaglandins and prostamines because of the change in the cycle of eyelash growth, namely due to the induction of the anagen phase into the telogen phase of the eyelash follicles.
Analogues of prostaglandins can also prolong the anagenic phase of eyelash growth, which leads to an increase in the length of the eyelashes, respectively.
Are prostaglandins effective for the treatment of alopecia areata (alopecia areata)?
Although prostaglandins are effective for increasing the growth of healthy hairs, its effectiveness with alopecia areata (alopecia areata) is being questioned, and the protective effect is not sufficiently studied in patients with loss of eyelashes due to chemotherapy or radiation. There are studies that describe a good result of the use of prostaglandins including latanoprost and bimatoprost in the treatment of lesions of the eyelids with alopecia areata in 11 year old patients suffering from alopecia areata with bilateral loss of eyelashes. At the same time, a poor result from treatment with latanoprost and bimatoprost locally to improve the growth of eyelashes in patients with aratea alopecia has also been described. Hence we conclude: everything is very individual.
Which remedy with prostaglandins is better: drops from glaucoma or conditioner for the growth of eyelashes with prostaglandins?
Many people, frightened by the possible side effects of using drops from glaucoma, use conditioners to stimulate the growth of eyelashes. Forgetting one thing - many of these conditioners contain in their composition prostaglandins and their analogs.
Thus, to the prostaglandins (with their side effects) in this case are added numerous irritants (already with their side effects), which even further intensifies the possible undesirable consequences. Therefore, replacing droplets from glaucoma on the conditioner to stimulate the growth of eyelashes (with prostaglandins in the composition) is not an option if you want to avoid side effects.
It's worth to take a closer look at the list of ingredients to make sure that you are using a natural conditioner (serum or serum) to grow eyelashes. The absence of prostaglandins does not mean that the bottle does not contain other irritating substances in your hands.
The advantage of droplets from glaucoma is that they contain a pure preparation without any irritants and additional preservatives. Buying a bubble of drops, you very much save, because you do not pay for the "theoretically working" (and possibly not acting on the growth of eyelashes) substances, emulsifiers, thickeners, fixing substances, etc. Having disassembled the most well-known conditioners that stimulate the growth of eyelashes, you will be surprised that these useless substances occupy most of the acquired tube. In addition, you will find that many substances are only useful theoretically, but no clinical trial has proven any positive effect in practice.
However, the conditioners for the growth of eyelashes have several advantages: a convenient brush-podvodka or (slightly less convenient) brush-brush for applying on eyelashes and the edge of the century at their roots. Of course, you can use a brush from the eyeliner or a brush from the carcass or a separate brush from the cosmetic set. I personally prefer solid brushes for liquid podvodki (penultimate in the photo): they are very easy to apply at the roots, with a bristle brush it is more difficult to regulate the clarity of the application (at least to me), brushes for the carcass cause the remedy over the entire length of the eyelashes (which is good for A natural conditioner, but unnecessary for drops from glaucoma, where the substance must be delivered to the roots of the hairs).